京都大学大学院医学研究科 血液・腫瘍内科学

研究

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研究業績（2020年1-12月）

LIST OF PUBLICATIONS

英文

  1. Hamada R, Kondo T, Murao M, Miyasaka J, Yoshida M, Nankaku M, Kanda J, Takaori-Kondo A, Ikeguchi R, Matsuda S. Effect of the severity of acute graft-versus-host disease on physical function after allogeneic hematopoietic stem cell transplantation. Support Care Cancer. 28(7): 3189-3196, 2020.
  2. Tamura N, Maeda H, Nishikori M, Fujita H, Hishizawa M, Haga H, Takaori-Kondo A. Histologic transformation of t(11;18)-positive MALT lymphoma presented with aberrant T-cell marker expression. Int J Hematol. 111(5): 724-732, 2020.
  3. Yamazaki H, Shirakawa K, Matsumoto T, Kazuma Y, Matsui H, Horisawa Y, Stanford E, Sarca AD, Shirakawa R, Shindo K, Takaori-Kondo A. APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression. PLoS One. 15(1): e0223463, 2020.
  4. Otsuka Y, Nishikori M, Arima H, Izumi K, Kitawaki T, Hishizawa M, Takaori-Kondo A. EZH2 inhibitors restore epigenetically silenced CD58 expression in B-cell lymphomas. Mol Immunol. 119: 35-45, 2020.
  5. Kimura S, Imagawa J, Murai K, Hino M, Kitawaki T, Okada M, Tanaka H, Shindo M, Kumagai T, Ikezoe T, Uoshima N, Sato T, Watanabe R, Kowata S, Hayakawa M, Hosoki T, Ikeda K, Kobayashi T, Kakinoki Y, Nishimoto T, Takezako N, Shibayama H, Takaori-Kondo A, Nakamae H, Kawaguchi A, Ureshino H, Sakamoto J, Ishida Y; DADI Trial Group. Treatment-free remission after first-line dasatinib discontinuation in patients with chronic myeloid leukaemia (first-line DADI trial): a single-arm, multicentre, phase 2 trial. Lancet Haematol. 7(3): e218-e225, 2020.
  6. Wada F, Kondo T, Nakamura M, Chonabayashi K, Nishikori M, Hishizawa M, Yamashita K, Takaori-Kondo A. Successful treatment of Hodgkin lymphoma-like EBV-associated post-transplant lymphoproliferative disorder following allogeneic hematopoietic stem cell transplantation with nivolumab. Ann Hematol. 99(4): 887-889, 2020.
  7. Sugimoto A, Kataoka TR, Ito H, Kitamura K, Saito N, Hirata M, Ueshima C, Takei Y, Moriyoshi K, Otsuka Y, Nishikori M, Takaori-Kondo A, Haga H. SLAM family member 8 is expressed in and enhances the growth of anaplastic large cell lymphoma. Sci Rep. 10(1): 2505, 2020.
  8. Radwan MO, Takaya D, Koga R, Iwamaru K, Tateishi H, Ali TFS, Takaori-Kondo A, Otsuka M, Honma T, Fujita M. Interruption of Vif/Elongin C interaction: In silico and experimental elucidation of the underlying molecular mechanism of benzimidazole-based APOBEC3G stabilizers. Bioorg Med Chem. 28(8): 115409, 2020.
  9. Nagano S, Maeda T, Ichise H, Kashima S, Ohtaka M, Nakanishi M, Kitawaki T, Kadowaki N, Takaori-Kondo A, Masuda K, Kawamoto H. High Frequency Production of T Cell-Derived iPSC Clones Capable of Generating Potent Cytotoxic T Cells. Mol Ther Methods Clin Dev. 16: 126-135, 2020.
  10. Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M. Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients. Haematologica. 105(4): 1166-1167, 2020.
  11. Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato TA, Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S. Combined Cohesin-Runx1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes. Cancer Discov. 10(6): 836-853, 2020.
  12. Watanabe T, Nishimura M, Izumi T, Kuriyama K, Iwaisako Y, Hosokawa K, Takaori-Kondo A, Fujimuro M. Kaposi's Sarcoma-Associated Herpesvirus ORF66 Is Essential for Late Gene Expression and Virus Production via Interaction With ORF34. J Virol. 94(2): e01300-19, 2020.
  13. Donovan FX, Solanki A, Mori M, Chavan N, George M, C SK, Okuno Y, Muramastsu H, Yoshida K, Shimamoto A, Takaori-Kondo A, Yabe H, Ogawa S, Kojima S, Yabe M, Ramanagoudr-Bhojappa R, Smogorzewska A, Mohan S, Rajendran A, Auerbach AD, Takata M, Chandrasekharappa SC, Vundinti BR. A Founder Variant in the South Asian Population Leads to a High Prevalence of FANCL Fanconi Anemia Cases in India. Hum Mutat. 41(1): 122-128, 2020.
  14. Jo T, Nishikori M, Kogure Y, Arima H, Sasaki K, Sasaki Y, Nakagawa T, Iwai F, Momose S, Shiraishi A, Kiyonari H, Kagaya N, Onuki T, Shin-Ya K, Yoshida M, Kataoka K, Ogawa S, Iwai K, Takaori-Kondo A. LUBAC Accelerates B-cell Lymphomagenesis by Conferring B Cells Resistance to Genotoxic Stress. Blood. 136(6): 684-697, 2020.
  15. Tatsumi G, Kawahara M, Yamamoto R, Hishizawa M, Kito K, Suzuki T, Takaori-Kondo A, Andoh A. LSD1-mediated Repression of GFI1 Super-Enhancer Plays an Essential Role in Erythroleukemia. Leukemia. 34(3): 746-758, 2020.
  16. Horisawa Y, Kondo T, Hishizawa M, Yamashita K, Takaori-Kondo A. A Case of Allogeneic Hematopoietic Stem Cell Transplantation for Primary Plasma Cell Leukemia After Treatment With Daratumumab. Ann Hematol. 99(11): 2699-2701, 2020.
  17. Muranushi H, Kanda J, Arai Y, Shindo T, Hishizawa M, Yamamoto T, Kondo T, Yamashita K, Matsubara K, Takaori-Kondo A. Drug Monitoring for Mycophenolic Acid in Graft-Vs-Host Disease Prophylaxis in Cord Blood Transplantation. Br J Clin Pharmacol. 86(12): 2464-2472, 2020.
  18. Watanabe M, Kanda J, Hishizawa M, Nishikori M, Kondo T, Yamashita K, Takaori-Kondo A. Lymphopenia at diagnosis predicts survival of patients with immunodeficiency-associated lymphoproliferative disorders. Ann Hematol. 99(7): 1565-1573, 2020.
  19. Nagata K, Shindo K, Matsui Y, Shirakawa K, Takaori-Kondo A. Critical Role of PP2A-B56 Family Protein Degradation in HIV-1 Vif Mediated G2 Cell Cycle Arrest. Biochem Biophys Res Commun. 527(1): 257-263, 2020.
  20. Takei H, Fukuda H, Pan G, Yamazaki H, Matsumoto T, Kazuma Y, Fujii M, Nakayama S, Kobayashi IS, Shindo K, Yamashita R, Shirakawa K, Takaori-Kondo A, Kobayashi SS. Alternative Splicing of APOBEC3D Generates Functional Diversity and Its Role as a DNA Mutator. Int J Hematol. 112(3): 395-408, 2020.
  21. Izumi K, Nishikori M, Yuan H, Otsuka Y, Nakao K, Takaori-Kondo A. Establishment and Characterization of a MALT Lymphoma Cell Line Carrying an API2-MALT1 Translocation. Genes Chromosomes Cancer. 59(9): 517-524, 2020.
  22. Fujishiro A, Iwasa M, Fujii S, Maekawa T, Andoh A, Tohyama K, Takaori-Kondo A, Miura Y. Menatetrenone facilitates hematopoietic cell generation in a manner that is dependent on human bone marrow mesenchymal stromal/stem cells. Int J Hematol. 112(3): 316-330, 2020.
  23. Tamura N, Maeda H, Nishikori M, Fujita H, Hishizawa M, Haga H, Takaori-Kondo A. Correction to: Histologic transformation of t(11;18)-positive MALT lymphoma presented with aberrant T-cell marker expression. Int J Hematol. 112(2): 265, 2020.
  24. Matsui H, Arai Y, Imoto H, Mitsuyoshi T, Tamura N, Kondo T, Kanda J, Ishikawa T, Imada K, Ueda Y, Toda Y, Anzai N, Yago K, Nohgawa M, Yonezawa A, Tsunemine H, Itoh M, Yamamoto K, Tsuji M, Moriguchi T, Takaori-Kondo A; Kyoto Stem Cell Transplantation Group (KSCTG). Risk factors and appropriate therapeutic strategies for thrombotic microangiopathy after allogeneic HSCT. Blood Adv. 4(13): 3169-3179, 2020.
  25. Okamoto Y, Abe M, Mu A, Tempaku Y, Rogers CB, Mochizuki AL, Katsuki Y, Kanemaki MT, Takaori-Kondo A, Sobeck AT, Bielinsky AK, Takata M. SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells. Blood. 2020.
  26. Watanabe M, Kanda J, Arai Y, Hishizawa M, Nishikori M, Ishikawa T, Imada K, Ueda Y, Akasaka T, Yonezawa A, Nohgawa M, Kitano T, Itoh M, Takeoka T, Moriguchi T, Yago K, Arima N, Anzai N, Watanabe M, Kondo T, Takaori-Kondo A; Kyoto Stem Cell Transplantation Group (KSCTG). Impact of donor source on allogeneic hematopoietic stem cell transplantation for mature T- and NK-cell neoplasms in the Kyoto Stem Cell Transplantation Group. Biol Blood Marrow Transplant. 26(12): 2346-2358, 2020.
  27. Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, Papaemmanuil E. Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. Nat Med. 26(10):1549-1556, 2020.
  28. Nakaya A, Tanaka H, Yagi H, Ohta K, Shibayama H, Kohara T, Kanda J, Shindo M, Shimura Y, Kosugi S, Kida T, Kaneko H, Imada K, Karasuno T, Matsuda M, Iida M, Adachi Y, Fuchida SI, Uoshima N, Uchiyama H, Takahashi R, Matsui T, Wada K, Kiyota M, Shimazaki C, Hino M, Kuroda J, Kanakura Y, Takaori-Kondo A, Nomura S, Matsumura I; Kansai Myeloma Forum Investigators. Retrospective analysis of plasmacytoma in Kansai Myeloma Forum Registry. Int J Hematol. 112(5): 666-673, 2020.
  29. Yamashita K, Takaori-Kondo A, Mizugishi K. Exaggerated neutrophil extracellular trap formation in Kawasaki disease: a key phenomenon behind the outbreak in western countries? Ann Rheum Dis. annrheumdis-2020-218593, 2020.
  30. Nagahata Y, Kondo T, Ono Y, Hiramoto N, Kitano T, Hishizawa M, Yamashita K, Hashimoto H, Ishikawa T, Takaori-Kondo A. High-dose cytarabine chemotherapy (≥4 g/m2/day) before allogeneic hematopoietic stem cell transplantation for non-core-binding-factor AML in the first complete remission. Leuk Lymphoma. 61(13): 3128-3136, 2020.
  31. Fujishiro A, Iwasa M, Fujii S, Maekawa T, Andoh A, Tohyama K, Takaori-Kondo A, Miura Y. Correction to: Menatetrenone facilitates hematopoietic cell generation in a manner that is dependent on human bone marrow mesenchymal stromal/stem cells. Int J Hematol. 112(4): 599-602, 2020.
  32. Nakaya A, Kohara T, Shibayama H, Onda Y, Kanda J, Kaneko H, Imada K, Kida T, Kosugi S, Ishikawa J, Yamamura R, Shimazu Y, Tanaka H, Fuchida SI, Shimura Y, Kiyota M, Wada K, Ito T, Uoshima N, Yagi H, Yoshihara S, Ohta K, Shimazaki C, Hino M, Takaori-Kondo A, Kuroda J, Matsumura I, Kanakura Y, Nomura S; Kansai Myeloma Forum Investigators. Retrospective multi-center study of Adolescent and Young Adult (AYA) Multiple Myeloma in Kansai Myeloma Forum registry. Int J Hematol. 112(4): 435-438, 2020.
  33. Ishino R, Kawase Y, Kitawaki T, Sugimoto N, Oku M, Uchida S, Imataki O, Matsuoka A, Taoka T, Kawakami K, van Kuppevelt TH, Todo T, Takaori-Kondo A, Kadowaki N. Oncolytic Virus Therapy with HSV-1 for Hematological Malignancies. Mol Ther. S1525-0016(20)30498-6, 2020.
  34. Ishiyama K, Kitawaki T, Otsuka Y, Takaori-Kondo A, Kadowaki N. PD-1-expressing CD56-negative NK cell expansion is a hallmark of chronic NK cell activation during dasatinib treatment. Cancer Sci. 2020.
  35. Onda Y, Kanda J, Sakamoto S, Okada M, Anzai N, Umadome H, Tashima M, Haga H, Watanabe C, Hanaoka N, Fujimoto T, Takaori-Kondo A. Detection of Adenovirus Hepatitis and Acute Liver Failure in Allogeneic Hematopoietic Stem Cell Transplant Patients. Transpl Infect Dis. 2020.
  36. Matsuo H, Wakita T, Hiramatsu H, Ohmori K, Kodama K, Nakatani K, Kamikubo Y, Iwamoto S, Kondo T, Takaori-Kondo A, Takita J, Tomizawa D, Taga T, Adachi S. Blast cells in acute megakaryoblastic leukaemia with Down syndrome are characterized by low CLEC12A expression. Br J Haematol. 2020.
  37. Wada F, Nishikori M, Hishizawa M, Watanabe M, Aiba A, Kitano T, Shimazu Y, Shindo T, Kondo T, Takaori-Kondo A. Secondary failure of platelet recovery in patients treated with high-dose thiotepa and busulfan followed by autologous stem cell transplantation. Int J Hematol. 112(5): 609-613, 2020..
  38. Tada S, Anazawa T, Shindo T, Yamane K, Inoguchi K, Nagai K, Masui Y, Okajima H, Takaori K, Sumi S, Uemoto S. The MEK inhibitor trametinib suppresses major histocompatibility antigen-mismatched rejection following pancreatic islet transplantation. Transplant Direct. 6(9): e591, 2020.
  39. Otsuka Y, Nishikori M, Fujimoto M, Nakao K, Hishizawa M, Haga H, Takaori-Kondo A. Relapse of follicular lymphoma arising from a non-t(14;18) clone. eJHaem. 1: 323-327, 2020.
  40. Maeda T, Nagano S, Kashima S, Terada K, Agata Y, Ichise H, Ohtaka M, Nakanishi M, Fujiki F, Sugiyama H, Kitawaki T, Kadowaki N, Takaori-Kondo A, Masuda K, Kawamoto H. Regeneration of Tumor-Antigen-Specific Cytotoxic T Lymphocytes from iPSCs Transduced with Exogenous TCR Genes. Mol Ther Methods Clin Dev. 19: 250-260, 2020.
  41. Wada F, Kondo T, Nakamura M, Uno S, Fujimoto M, Miyamoto T, Honda Y, Shibata H, Izawa K, Yasumi T, Nishikori M, Takaori-Kondo A. EBV-associated lymphoproliferative disorder in a patient with X-linked severe combined immunodeficiency with multiple reversions of an IL2RG mutation in T cells. eJHaem. 1: 581-584, 2020.
  42. Noguchi M, Chen-Yoshikawa TF, Arai Y, MD, Kondo T, Hiramatsu H, Tanaka S, Yamada Y, Yutaka Y, Nakajima D, Hamaji M, Ohsum A, Takita J, Takaori-Kondo A, Date H. Expanded indications for lung transplantation for pulmonary complications after hematopoietic stem cell transplantation. J Thorac Cardiovasc Surg. S0022-5223(20)32887-7, 2020.
  43. Iemura T, Arai Y, Kanda J, Kitawaki T, Hishizawa M, KondoT, Yamashita K, Takaori-Kondo A. Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation. Sci Rep. 10(1): 21150, 2020.
  44. Morita-Fujita M, Arai Y, Yoshioka S, Ishikawa T, Kanda J, Kondo T, Akasaka T, Ueda Y, Imada K, Moriguchi T, Yago K, Kitano T, Yonezawa A, Nohgawa M, Takaori-Kondo A on behalf of Kyoto Stem Cell Transplantation Group (KSCTG). Indication and benefit of upfront hematopoietic stem cell transplantation for T-cell lymphoblastic lymphoma in the era of ALL-type induction therapies. Sci Rep. 10(1): 21418, 2020.